Xiao Zhen Zhou Selected Research

Peptidylprolyl Isomerase (Prolyl Isomerase)

1/2021	Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
1/2021	Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
1/2020	PIN1 Inhibition Sensitizes Chemotherapy in Gastric Cancer Cells by Targeting Stem Cell-like Traits and Multiple Biomarkers.
1/2020	Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition.
1/2020	Identification of a potent and selective covalent Pin1 inhibitor.
8/2019	Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis.
1/2019	Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K/AKT and Wnt/β-catenin oncogenic pathways.
1/2019	Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms.
5/2017	Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.
1/2017	Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways.

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Xiao Zhen Zhou Research Topics

Disease

32	Neoplasms (Cancer) 01/2021 - 01/2006
12	Carcinogenesis 08/2019 - 06/2006
10	Alzheimer Disease (Alzheimer's Disease) 09/2020 - 07/2003
7	Breast Neoplasms (Breast Cancer) 01/2020 - 07/2013
4	Leukemia 01/2018 - 08/2007
3	Adenocarcinoma 01/2021 - 08/2019
3	Neoplasm Metastasis (Metastasis) 01/2020 - 07/2009
3	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 01/2017
3	Acute Promyelocytic Leukemia 01/2018 - 05/2015
3	Amyloid Plaque 03/2012 - 03/2006
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021 - 07/2015
2	Triple Negative Breast Neoplasms 01/2020 - 01/2018
2	Stomach Neoplasms (Stomach Cancer) 01/2020 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2019 - 01/2018
2	Liver Neoplasms (Liver Cancer) 10/2018 - 01/2018
2	Tauopathies 01/2018 - 07/2015
2	Inflammation (Inflammations) 01/2018 - 12/2010
2	Chronic Traumatic Encephalopathy 01/2018 - 07/2015
2	Chromosomal Instability (Chromosome Stability) 10/2011 - 04/2011
1	Epilepsy (Aura) 10/2021
1	Dementia (Dementias) 01/2021
1	Cognitive Dysfunction 01/2021
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Brain Injuries (Brain Injury) 01/2019
1	Overactive Urinary Bladder (Overactive Bladder) 01/2019
1	Neuroinflammatory Diseases 01/2019
1	Arthrogryposis renal dysfunction cholestasis syndrome 01/2019
1	Asthma (Bronchial Asthma) 01/2018
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018
1	Hypoxia (Hypoxemia) 08/2014
1	Premature Aging 11/2012

Drug/Important Bio-Agent (IBA)

24	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 01/2021 - 02/2006
11	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2020 - 05/2015
11	Proteins (Proteins, Gene)FDA Link 01/2018 - 07/2003
8	Pharmaceutical PreparationsIBA 01/2021 - 06/2012
7	Proline (L-Proline)FDA Link 01/2019 - 07/2003
5	IsomerasesIBA 01/2019 - 05/2015
4	Death-Associated Protein KinasesIBA 01/2021 - 04/2011
3	Small Interfering RNA (siRNA)IBA 01/2020 - 06/2009
3	Oncogene Proteins (Oncogene Protein)IBA 01/2019 - 06/2012
3	NIMA-Interacting Peptidylprolyl IsomeraseIBA 01/2019 - 07/2013
3	Phosphotransferases (Kinase)IBA 01/2018 - 04/2011
3	Amyloid (Amyloid Fibrils)IBA 03/2012 - 03/2006
3	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2011 - 01/2006
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2018
2	MicroRNAs (MicroRNA)IBA 01/2018 - 01/2017
2	tau Proteins (tau Protein)IBA 01/2016 - 07/2015
2	Biological ProductsIBA 10/2015 - 06/2012
2	Antineoplastic Agents (Antineoplastics)IBA 10/2015 - 06/2006
2	Serine (L-Serine)FDA Link 07/2009 - 07/2003
2	Amyloid beta-PeptidesIBA 07/2006 - 03/2006
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 10/2021
1	Gemcitabine FDA Link 01/2021
1	LigandsIBA 01/2021
1	MelatoninIBA 09/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	BRCA1 ProteinIBA 01/2020
1	olaparibIBA 01/2020
1	CateninsIBA 01/2019
1	Estrogen Receptor AntagonistsIBA 01/2019
1	Monoclonal AntibodiesIBA 01/2019
1	Immunoglobulin G (IgG)IBA 01/2019
1	Cadherins (E-Cadherin)IBA 01/2019
1	regorafenibIBA 01/2019
1	Estrogen ReceptorsIBA 01/2019
1	TabletsIBA 01/2019
1	Tamoxifen FDA LinkGeneric 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2019
1	Delayed-Action PreparationsIBA 10/2018
1	ArsenicIBA 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	cis-trans-IsomerasesIBA 01/2018
1	Trypan Blue FDA Link 01/2018
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2018
1	Arsenic Trioxide (Trisenox)FDA Link 01/2018
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018
1	CytokinesIBA 01/2018
1	PrionsIBA 01/2018
1	Interleukin-33IBA 01/2018
1	Interleukin Receptors (Interleukin Receptor)IBA 01/2018
1	Sorafenib (BAY 43-9006)FDA Link 05/2017
1	CaspasesIBA 05/2017
1	Histone Deacetylase 6IBA 11/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2016
1	Phenobarbital (Luminal)FDA Link 11/2016
1	G-Protein-Coupled Receptor Kinase 2IBA 11/2016
1	EnzymesIBA 10/2015
1	Phosphates (Orthophosphate)IBA 05/2015
1	GTP Phosphohydrolases (GTPases)IBA 04/2015
1	Oxygen (Dioxygen)IBA 08/2014
1	Transcription Factors (Transcription Factor)IBA 08/2014
1	sulfoenolpyruvateIBA 07/2013
1	Peptide Hydrolases (Proteases)FDA Link 07/2013
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2012
1	Paclitaxel (Taxol)FDA LinkGeneric 06/2012
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 06/2012
1	Cisplatin (Platino)FDA LinkGeneric 06/2012

Therapy/Procedure

10	Therapeutics 01/2021 - 06/2012
2	Immunotherapy 01/2021 - 01/2021
2	Drug Therapy (Chemotherapy) 01/2020 - 06/2012